John McLachlan John McLachlan, Ph.D. Dr. John McLachlan John A. McLachlan John A. McLachlan, Tulane University School of Medicine John A. McLachlan, Endocrinology John McLachlan, Professor of Pharmacology John McLachlan, Adjunct Professor of Ecology and Evolutionary Biology John McLachlan, Tulane University John A. McLachlan, Pharmacology Profesor John A. McLachlan, Endocrine Disruption

Selected Papers PubMed Publications 

  1. 2016, Thaddeus T. Schug, Anne F. Johnson, Linda S. Birnbaum, Theo Colborn, Louis J. Guillette, Jr David, Crews, Terry Collins, Ana M. Soto, Frederick S. vom Saal, John A. McLachlan, Carlos Sonnenschein, and Jerrold J. Heindel. Minireview: Endocrine Disruptors: Past Lessons and Future Directions, Molecular Endocrinology, Endocrine Society
  2. 2015, Strong, A.L., Shi, Z., Strong, T.A., Miller D., Rusch D.B., Buechlein, A., Flemington E.K., McLachlan, J.A., Nephew, K.P., Burow, M.E., Bunnell, B.A. Effects of the Endocrine-Disrupting Chemical DDT on Self-Renewal and Differentiation of Human Mesenchymal Stem Cells. Environmental Health Perspectives.
  3. 2013, Tilghman, S.L., Rhodes, L.V., Bratton, M.R., Carriere, Preyan, L.C., Boue, S.M., McLachlan, J.A., Burow, M.E. Phytoalexins, miRNAs and Breast Cancer: a review of phytochemical- mediated miRNA regulation in breast cancer. Journal of Healthcare for the Poor and Underserved
  4. 2013, Johnson, K.P., Johnson, D.E., Hawthorne, T., Gibbs, L., Burow, M.E., Rhodes, L.V., Gray, M., Tilghman, S.L., McLachlan, J.A., Ochieng, J. In Vitro and In Vivo Evaluation of Novel Anticancer Agents in Triple Negative Breast Cancer Models. Journal of Healthcare for the Poor and Underserved
  5. 2008, Bratton, Frigo, Vigh, Fan, Wadsworth, McLachlan, and Burow, Organochlorine mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase, Carcinogenesis
  6. 2008, Crain, Janssen, Edwards, Heindel, Ho, Hunt, Iguchi, Juul, McLachlan, Schwartz, Skakkebaek, Soto, Swan, Walker, Woodruff, Woodruff, Giudice, and Guillette, Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing, Fertility and Sterility
  7. 2008, Fox, Burow, McLachlan , Miller,Detecting ligands and dissecting nuclear receptor-signaling pathways using recombinant strains of the yeast Saccharomyces cerevisiae, Nature Protocols
  8. 2007, Wetherill, Akingbemi, Kanno, McLachlan, Nadal, Sonnenschein, Watson, Zoeller, Belcher, In vitro molecular mechanisms of bisphenol A action, Reproductive Toxicology
  9. 2007, vom Saal, Akingbemi, Belcherc, Birnbaum, Crain, Eriksen, Farabollini, Guillette, Hauser, Heinde, Shuk-Mei Ho, Hunt, Iguchi, Jobling, Kanno, Keri, Knudsen, Laufer, LeBlanc, Marcus, McLachlan, Myers, Nadal, Newbold, Olea, Prins, Richter, Rubin, Sonnenschein, Soto, Talsness, Vandenbergh, Vandenberg, Walser-Kuntz, Watson, Welshons, Wetherill and Zoeller, Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure, Reproductive Toxicology
  10. 2007, Fox, Gulledge, Engelhaupt, Burow, and McLachlan, Pesticides reduce symbiotic efficiency of nitrogen-fixing rhizobia and host plants, Proc Natl Acad Sci U S A
  11. 2006, Crews and McLachlan, Epigenetics, Evolution, Endocrine Disruption, Health, and Disease, Endocrinology
  12. 2006, McLachlan, Nierth-Simson, Martin, Endocrine disrupters and female reproductive health, Best Practice & Research Clinical Endocrinology and Metabolism
  13. 2006, Guillette, Conard, Lares, Aguilar, McLachlan, Guillette, Altered breast development in young girls from an agricultural environment, Environmental Health Perspectives
  14. 2006, Frigo, Basu, Nierth-Simpson, Weldon, Dugan, Elliott, Collins-Burow, Salvo, Zhu, Melnik, Lopez, Kushner, Curiel, Rowan, McLachlan, Burow, p38 MAPK Stimulates, Estrogen-Mediated transcription and proliferation through the phosphorylation and potentiation of the p160 coactivator GRIP1, Molecular Endocrinology
  15. 2006, McLachlan, Commentary: Prenatal exposure to DES: a continuing story, International Journal of Epidemiology
  16. 2005, Frigo, Vigh, Struckhoff, Elliott, Beckman, Burow, McLachlan, Xenobiotic-induced TNF-alpha expression and  apoptosis through the p38 MAPK signaling pathway, Toxicology Letters
  17. 2004, Frigo, Tang, Beckman, Scandurro, Alam, Burow, McLachlan, Mechanism of AP-1 mediated gene expression by select organochlorines through the p38 MAPK pathway , Carcinogenesis
  18. 2004, Fox, Starevic, Jones, Burow, McLachlan, Phytoestrogen Signaling and Symbiotic Gene Activation Are Disrupted by Endocrine-Disrupting Chemicals, Environmental Health Perspectives
  19. 2003, Li, Chiang, Richard-Davis, Barrett, McLachlan, DNA hypomethlyation and imbalanced expression of DNA methyltransferases in uterine leiomyomas, Gynecologic Oncology
  20. 2003 ,Li, Hansman, Newbold, Davis, McLachlan, Barrett, Neonatal diethylstilberstrol exposure induces persistent elevation of c-fos expression and hypomethylation in its exon-4 mouse uterus, Molecular Carcinogenesis
  21. 2003, Li, Hursting, Davis, McLachlan, Barrett, Environmental exposure, DNA Methlyation, and Gene Regulation, Annals of the NY Academy of Sciences
  22. 2003, Boue, Wiese, Nehls, Burow, Elliott, Carter-Wientjes, Shih, McLachlan, Cleveland, Evaluation of the Estrogenic Effects of Legume Extracts Containing Phytoestrogens, Journal of Agricultural and Food Chemistry
  23. 2002, Frigo, Duong, Melnik, Schief, Collins-Burow, Pace, McLachlan, Burow, Flavonoid Phytochemicals Regulate Activator Protein-1 Signal Transduction Pathways in Endometrial and Kidney Stable Cell Lines, Journal of Nutrition
  24. 2002, Frigo, Burow, Mitchell, Chiang, McLachlan, DDT and Its Metabolites Alter Gene Expression in Human Uterine Cell Lines Through Estrogen Receptor-Independent Mechanisms , Environmental Health Perspectives
  25. 2001, O'Neil, Burow, Green, McLachlan, Henson, Effects of estrogen on leptin gene promoter activation in MCF-7 breast cancer and JEG-3 chorocarcinoma cells, Molecular and Cellular Endocrinology
  26. 2001, Oberdorster, Clay, Cottam, Wilmot, McLachlan, Milner, Common phytochemicals are ecdysteroid agonists and antagonists: a possible evolutionary link between vertebrate and invertebrate steroid hormones, Journal of Steroid Biochemistry and Molecular Biology
  27. 2001, McLachlan, Burow, Chiang, Li, Gene imprinting in developmental toxicology; a possilbe interface between physiology and pathology, Toxicology Letters
  28. 2001, McLachlan, Environmental Signaling: what embryos and evolution teach us about endocrine disrupting chemicals, Endocrine Reviews
  29. 2001, Li, McLachlan, Estrogen-associated genes in uterine leiomyoma, Annals of the NY Academy of Sciences
  30. 2001, Li, Chiang, Richard-Davis, Williams, Wilson, McLachlan, Expression of Wnt7a is inversely associated with the expression of estrogen receptor alpha in human uterine leiomyoma, Journal of Clinical Endocrinology and Metabolism
  31. 2001, Li, Ma, Chiang, Burow, Newbold, Negishi, Barrett, McLachlan, Promoter CpG methylation of Hox-a 10 and Hox-a 11 in mouse uterus not altered upon neonatal diethylstilbestrol exposure, Molecular Carcinogenesis
  32. 2001, Cheek, Brouwer, Carroll, Manning, McLachlan, Brouwer, Experimental evaluation of vitellogenin as a predictive biomarker for reproductive disruption, Environmental Health Perspectives
  33. 2001, Burow, Boue, Collins-Burow, Melnik, Duong, Carter-Wientjes, Li, Wiese, Cleveland, McLachlan, Phytochemical glyceollins, isolated from soy, mediate antihormonal effects through estrogen receptor alpha and beta, Journal of Clinical Endocrinology and Metabolism
  34. 2001, Burow, Weldon, Tang, McLachlan, Beckman, Oestrogen-mediated suppression of tumour necrosis alpha-induced apoptosis in MCF-7 cells: subversion of Bcl-2 by anti-oestrogens, Journal of Steroid Biochemistry and Molecular Biology
  35. 2000, Newbold, Hanson, Jefferson, Bullock, Haseman, McLachlan, Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol, Carcinogenesis
  36. 1999, Burow, Tang, Collins-Burow, Krajewski, Reed, McLachlan, Beckman, Effects of environmental estrogens on tumor necrosis factor alpha mediated apoptosis in MCF-7 cells, Carcinogenesis
  37. 1997, Klotz, Ladlie, Vonier, McLachlan, Arnold, o,p'-DDT and its metabolites inhibit progesterone-dependent responses in yeast and human cells, Molecular and Cellular Endocrinology
  38. 1978, Korach, Metzler, McLachlan, Estrogenic activity in vivo and in vitro of some diethlystilbestrol metabolites and analogs, Proceedings of the National Academy of Sciences